Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	19	0.001	0.32	0.148	0.091
biological_process	el	19	0.52	0.971	0.867	0.104
biological_process	ka	19	0.0	0.332	0.134	0.091
biological_process	rf	19	0.001	0.32	0.148	0.091
disease	ct	9	0.032	0.666	0.344	0.242
disease	el	9	0.161	0.989	0.533	0.265
disease	ka	9	0.003	0.619	0.333	0.234
disease	rf	9	0.032	0.666	0.344	0.242
genetic_interaction	ct	17	0.0	0.975	0.544	0.31
genetic_interaction	el	17	0.0	0.976	0.557	0.306
genetic_interaction	ka	17	0.0	1.0	0.882	0.322
genetic_interaction	rf	17	0.0	0.965	0.545	0.307
molecular_function	ct	13	0.004	0.739	0.305	0.23
molecular_function	el	13	0.079	0.843	0.462	0.287
molecular_function	ka	13	0.009	0.749	0.306	0.236
molecular_function	rf	13	0.003	0.739	0.305	0.23
pathway	ct	19	0.001	0.901	0.491	0.299
pathway	el	19	0.001	0.793	0.412	0.294
pathway	ka	19	0.001	1.0	0.843	0.363
pathway	rf	19	0.001	0.785	0.387	0.268
phenotype	ct	7	0.007	0.627	0.402	0.252
phenotype	el	7	0.234	0.743	0.496	0.206
phenotype	ka	7	0.003	0.681	0.445	0.28
phenotype	rf	7	0.007	0.627	0.402	0.252
protein_interaction	ct	19	0.002	0.4	0.16	0.11
protein_interaction	el	19	0.003	0.258	0.091	0.07
protein_interaction	ka	19	0.008	1.0	0.74	0.435
protein_interaction	rf	19	0.002	0.386	0.149	0.104

Table 2. Backup position values for every kernel after integration

Integration	Kernel	Elements	Min	Max	Average	Standard_Deviation
integration_mean_by_presence	ct	19	0.006	0.983	0.408	0.332
integration_mean_by_presence	el	19	0.0	0.547	0.195	0.159
integration_mean_by_presence	ka	19	0.0	0.567	0.276	0.163
integration_mean_by_presence	rf	19	0.0	0.816	0.298	0.252
mean	ct	19	0.0	0.988	0.375	0.351
mean	el	19	0.0	0.332	0.11	0.107
mean	ka	19	0.0	0.393	0.147	0.109
mean	rf	19	0.0	0.333	0.142	0.113

CDF plots of non integrated kernels

CDF plots of integrated kernels