Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.001 0.32 0.148 0.091
biological_process el 19 0.52 0.971 0.867 0.104
biological_process ka 19 0.0 0.332 0.134 0.091
biological_process rf 19 0.001 0.32 0.148 0.091
disease ct 9 0.032 0.666 0.344 0.242
disease el 9 0.161 0.989 0.533 0.265
disease ka 9 0.003 0.619 0.333 0.234
disease rf 9 0.032 0.666 0.344 0.242
genetic_interaction ct 17 0.0 0.975 0.544 0.31
genetic_interaction el 17 0.0 0.976 0.557 0.306
genetic_interaction ka 17 0.0 1.0 0.882 0.322
genetic_interaction rf 17 0.0 0.965 0.545 0.307
molecular_function ct 13 0.004 0.739 0.305 0.23
molecular_function el 13 0.079 0.843 0.462 0.287
molecular_function ka 13 0.009 0.749 0.306 0.236
molecular_function rf 13 0.003 0.739 0.305 0.23
pathway ct 19 0.001 0.901 0.491 0.299
pathway el 19 0.001 0.793 0.412 0.294
pathway ka 19 0.001 1.0 0.843 0.363
pathway rf 19 0.001 0.785 0.387 0.268
phenotype ct 7 0.007 0.627 0.402 0.252
phenotype el 7 0.234 0.743 0.496 0.206
phenotype ka 7 0.003 0.681 0.445 0.28
phenotype rf 7 0.007 0.627 0.402 0.252
protein_interaction ct 19 0.002 0.4 0.16 0.11
protein_interaction el 19 0.003 0.258 0.091 0.07
protein_interaction ka 19 0.008 1.0 0.74 0.435
protein_interaction rf 19 0.002 0.386 0.149 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 19 0.006 0.983 0.408 0.332
integration_mean_by_presence el 19 0.0 0.547 0.195 0.159
integration_mean_by_presence ka 19 0.0 0.567 0.276 0.163
integration_mean_by_presence rf 19 0.0 0.816 0.298 0.252
mean ct 19 0.0 0.988 0.375 0.351
mean el 19 0.0 0.332 0.11 0.107
mean ka 19 0.0 0.393 0.147 0.109
mean rf 19 0.0 0.333 0.142 0.113

CDF plots of non integrated kernels

CDF plots of integrated kernels